The Inhibition Effects of Cetylpyridinium Chloride in Dentifrices on Plaque Formation: Clinical Test
Yoo Chang-Seon, Chae Sang-Kyun, 이현기, 김찬호, 김대경, 김왕기, 김기은, 안효광, 김지은, 오윤종, 유수민, 안금선, 황경숙, 권하정, 박용덕,
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( Yoo Chang-Seon ) - Kyung Hee University School of Dentistry Department of Preventive and Social Dentistry
( Chae Sang-Kyun ) - Amorepacific Corporation R&D Center Department of Personal Care Research
이현기 ( Lee Hyun-Gee ) - Amorepacific Corporation R&D Center Department of Personal Care Research
김찬호 ( Kim Chan-Ho ) - Amorepacific Corporation R&D Center Department of Personal Care Research
김대경 ( Kim Dae-Kyeong ) - Amorepacific Corporation R&D Center Department of Personal Care Research
김왕기 ( Kim Wang-Gi ) - Amorepacific Corporation R&D Center Department of Personal Care Research
김기은 ( Kim Ki-Eun ) - Kyung Hee University School of Dentistry Department of Preventive and Social Dentistry
안효광 ( Ahn Hyo-Kwang ) - Kyung Hee University School of Dentistry Department of Preventive and Social Dentistry
김지은 ( Kim Ji-Eun ) - Kyung Hee University School of Dentistry Department of Preventive and Social Dentistry
오윤종 ( Oh Yoon-Jong ) - Kyung Hee University School of Dentistry Department of Preventive and Social Dentistry
유수민 ( Yoo Su-Min ) - Kyungdong University Department of Dental Hygiene
안금선 ( Ahn Geum-Sun ) - Kyungbok University Department of Dental Hygiene
황경숙 ( Hwang Kyung-Suk ) - Shinhan University College of Health Science Department of Dental Technology
권하정 ( Kwon Ha-Jeong ) - Kyung Hee University School of Dentistry Department of Preventive and Social Dentistry
박용덕 ( Park Yong-Duk ) - Kyung Hee University School of Dentistry Department of Preventive and Social Dentistry
KMID : 1157520140100010009
Abstract
Objective: Various kinds of anti-plaque agents are mixed to dentifrices in order to prevent oral diseases. This study is to evaluatethe efficacy on plaque index and safety of dentifrice containing cetylpyridinium chloride by in vitro test and clinical test.
Methods: Streptococcus mutans (KCTC3065) was incubated for 24 hours. After mucin treatment of hydroxyapatite disks, opticaldensity measurement was performed at 590 nm to compare anti-plaque effects. Clinical tests was performed by doubleblind test after using control dentifrice for 2 weeks and setting baseline to 40 of Korean adults. The oral hygiene index wasinvestigated during the use of control and experimental dentifrices samples twice-daily for 12 weeks.
Results: In vitro test showed the anti-plaque efficacy of experimental group was significantly increased 54.3% than controlgroup (p＜0.05). In addition, in vivo test shows the O’Leary plaque index of experimental group were improved 53.6% thancontrol group (p＜0.05), and the persons’ effect ratio was 80.0% (p＜0.05).
Conclusion: Cetylpyridinium chloride in dentifrice significantly inhibited the growth of dental plaque and advanced the oralhygiene index.
키워드
dental plaque; cetylpyridinium; dentifrices; glycyrrhizinic acid
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